A76109

Sigma-Aldrich

3-Amino-1-propanesulfonic acid

97%

Synonym(s):
3APS, Tramiprosate, Homotaurine
Linear Formula:
H2N(CH2)3SO3H
CAS Number:
Molecular Weight:
139.17
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

97%

mp

293 °C (dec.) (lit.)

SMILES string

NCCCS(O)(=O)=O

InChI

1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

InChI key

SNKZJIOFVMKAOJ-UHFFFAOYSA-N

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Related Categories

Application

Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).

Packaging

1, 5 g in glass bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A76109.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

D Saumier et al.
The journal of nutrition, health & aging, 13(9), 808-812 (2009-10-09)
Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the...
J Y Wu et al.
Journal of biomedical science, 8(1), 96-103 (2001-02-15)
Acamprosate (AC), N-acetyl-homotaurine, has recently been introduced for treating alcohol craving and reducing relapses in weaned alcoholics. AC may exert its action through the taurine system rather than the glutamatergic or GABAergic system. This conclusion is based on the observations...
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 55(2), 282-287 (2011-02-18)
Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid β (Aβ) protein. A simple and rapid method using HPLC with fluorescence detector was developed and validated for determination of tramiprosate in rat plasma. Pre-column derivatization of...
S Gauthier et al.
The journal of nutrition, health & aging, 13(6), 550-557 (2009-06-19)
The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer's disease (AD), the Alphase study. Disease-modification was assessed using longitudinal volumetric MRI (vMRI) measurements of...
P S Aisen et al.
Neurology, 67(10), 1757-1763 (2006-11-04)
As a potential disease-modifying treatment for Alzheimer disease (AD), 3-amino-1-propanesulfonic acid (3APS) is a compound that binds to amyloid beta (Abeta), a toxic protein known to aggregate, leading to amyloid plaque deposition in the brain. We assessed the safety, tolerability...

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