All Photos(1)

P30004

Sigma-Aldrich

1-Phenylpiperazine

99%

Synonym(s):
N-Phenyldiethylenediamine
Empirical Formula (Hill Notation):
C10H14N2
CAS Number:
Molecular Weight:
162.23
Beilstein:
132157
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

assay

99%

refractive index

n20/D 1.588 (lit.)

bp

286 °C (lit.)

density

1.062 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ccccc2

InChI

1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2

InChI key

YZTJYBJCZXZGCT-UHFFFAOYSA-N

Gene Information

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Pictograms

CorrosionSkull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

284.0 °F

Flash Point(C)

140 °C

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Gilda Neves et al.
Pharmacology, biochemistry, and behavior, 89(1), 23-30 (2007-12-18)
Previous studies have demonstrated that LASSBio-579 and LASSBio-581, two N-phenylpiperazine derivatives designed for the treatment of schizophrenia, are presynaptic dopamine D(2) receptor agonists that induce a hypothermic effect in mice that is not mediated by dopamine receptor activation. The aim...
Jadwiga Handzlik et al.
Bioorganic & medicinal chemistry, 20(7), 2290-2303 (2012-03-03)
An association between α(1)-adrenoceptor affinities, hERG K(+)-antagonistic properties and antiarrhythmic activities for a series of phenylpiperazine derivatives of hydantoin (2a-21a) was investigated. New compounds were synthesized and tested for their affinity for α(1)-adrenoceptors in radioligand binding assay using [(3)H]-prazosin as...
Daniela Poli et al.
Journal of medicinal chemistry, 54(7), 2102-2113 (2011-03-16)
Following a molecular simplification approach, we have identified the 2-phenylphthalazin-1(2H)-one (PHTZ) ring system as a new decorable core skeleton for the design of novel hA(3) adenosine receptor (AR) antagonists. Interest for this new series was driven by the structural similarity...
Rodolfo do Couto Maia et al.
Expert opinion on therapeutic patents, 22(10), 1169-1178 (2012-09-11)
The N-phenylpiperazine subunit represents one of the most versatile scaffolds used in the medicinal chemistry field. Recently, some N-phenylpiperazine derivatives have reached late stage clinical trials for the treatment of CNS disorders, thus, this is clearly a molecular template that...
Romano Di Fabio et al.
Journal of medicinal chemistry, 52(10), 3238-3247 (2009-04-25)
In an effort to discover novel druglike NK(1) receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specific aim to maximize their in vitro affinity and...

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