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T34908

Sigma-Aldrich

D-Thyroxine

99%

Synonym(s):
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-D-alanine, 3,3′,5,5′-Tetraiodo-D-thyronine
Empirical Formula (Hill Notation):
C15H11I4NO4
CAS Number:
Molecular Weight:
776.87
Beilstein:
2954910
MDL number:
PubChem Substance ID:

assay

99%

mp

~235 °C (dec.)

SMILES string

N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1

InChI key

XUIIKFGFIJCVMT-GFCCVEGCSA-N

Gene Information

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Certificate of Analysis

Certificate of Origin

Dextrothyroxine induced hyperthyroidism in a patient with heterozygous familial hypercholesterolaemia.
H J Hazenberg et al.
The Netherlands journal of medicine, 31(3-4), 117-121 (1987-10-01)
F A Karlsson et al.
Acta endocrinologica, 129(4), 291-295 (1993-10-01)
A unique thyrotrophin (TSH)-secreting pituitary tumour is described in a patient with a history of recurrent thyrotoxicosis. Unlike other previously reported TSHomas, the tumour is insensitive to octreotide, a somatostatin analogue. It does not accumulate [111In]octreotide but expresses functional dopamine
G S Sandhu et al.
Magnetic resonance in medicine, 18(1), 237-243 (1991-03-01)
31P NMR spectroscopy was used to monitor the cardiac energy metabolism in hypothyroid rat hearts. Differential alterations in phosphocreatine and inorganic phosphate levels were observed upon treatment of hypothyroid animals with DT4 and LT4, while both agents were equipotent in
Purified D-thyroxine in athyreotic patients.
P Hamon et al.
Lancet (London, England), 341(8858), 1477-1477 (1993-06-05)
P L Canner et al.
Journal of the American College of Cardiology, 8(6), 1245-1255 (1986-12-01)
The Coronary Drug Project was conducted between 1966 and 1975 to assess the long-term efficacy and safety of five lipid-influencing drugs in 8,341 men aged 30 to 64 years with electrocardiogram-documented previous myocardial infarction. The two estrogen regimens and dextrothyroxine

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