All Photos(1)

W387101

Sigma-Aldrich

4-Methyl-2-oxopentanoic acid sodium salt

97%

Synonym(s):
Ketoleucine sodium salt, α-Ketoisocaproic acid sodium salt, 4-Methyl-2-oxopentanoic acid sodium salt, Sodium 4-methyl-2-oxovalerate, 4-Methyl-2-oxovaleric acid sodium salt
Linear Formula:
(CH3)2CHCH2COCOONa
CAS Number:
Molecular Weight:
152.12
FEMA Number:
3871
Beilstein:
4239297
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

biological source

synthetic

assay

97%

mp

275 °C (dec.) (lit.)

Documentation

see Safety & Documentation for available documents

Featured Industry

Flavors and Fragrances

Organoleptic

buttery

food allergen

no known allergens

SMILES string

[Na+].CC(C)CC(=O)C([O-])=O

InChI

1S/C6H10O3.Na/c1-4(2)3-5(7)6(8)9;/h4H,3H2,1-2H3,(H,8,9);/q;+1/p-1

InChI key

IXFAZKRLPPMQEO-UHFFFAOYSA-M

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Certificate of Analysis

Certificate of Origin

Benjamin Wax et al.
Journal of dietary supplements, 10(1), 6-16 (2013-01-30)
Glycine-arginine-α-ketoisocaproic acid (GAKIC) has been proposed to increase anaerobic high-intensity exercise performance in male subjects. However, the effects of GAKIC ingestion in female subjects have not been studied. Therefore, the purpose of this study was to investigate the effects of...
Li Qi et al.
Talanta, 81(4-5), 1554-1559 (2010-05-06)
A new strategy for the enantioseparation of D,L-amino acids employing the principle of ligand exchange capillary electrophoresis with Zn(II)-L-valine complex as a chiral selecting system in the presence of beta-cyclodextrin has been designed. Successful enantioseparation of label free and labeled...
Yuhong Zhu et al.
Enzyme and microbial technology, 49(4), 321-325 (2011-11-25)
This work aims to produce α-ketoisocaproate (KIC) from L-leucine via the free-whole-cell biotransformation of Rhodococcus opacus DSM 43250. The effects of temperature, pH, substrate concentration, cell concentration, and rotating speed on KIC production were examined. Furthermore, the biotransformation conditions were...
Nelo Eidy Zanchi et al.
Amino acids, 40(4), 1015-1025 (2010-07-08)
Amino acids such as leucine and its metabolite α-ketoisocaproate (KIC), are returning to be the focus of studies, mainly because of their anti-catabolic properties, through inhibition of muscle proteolysis and enhancement of protein synthesis. It is clear that these effects...
Chung-De Chen et al.
Journal of bacteriology, 194(22), 6206-6216 (2012-09-18)
Branched-chain aminotransferases (BCAT), which utilize pyridoxal 5'-phosphate (PLP) as a cofactor, reversibly catalyze the transfer of the α-amino groups of three of the most hydrophobic branched-chain amino acids (BCAA), leucine, isoleucine, and valine, to α-ketoglutarate to form the respective branched-chain...

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