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W527718

Sigma-Aldrich

L-Valine

FCC

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Synonym(s):
(S)-α-Aminoisovaleric acid, L-2-Amino-3-methylbutanoic acid
Linear Formula:
(CH3)2CHCH(NH2)CO2H
CAS Number:
Molecular Weight:
117.15
Beilstein:
1721136
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
Flavis number:
17.028

biological source

microbial

Quality Level

reg. compliance

FCC
FDA 21 CFR 172.320

optical activity

[α]20/D +26.7 to +29.0°, c = 8 in 6 M HCl

mp

295-300 °C (subl.) (lit.)

solubility

1 M HCl: soluble 88.5 g/L at 25 °C (completely)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

odorless

SMILES string

CC(C)[C@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

InChI key

KZSNJWFQEVHDMF-BYPYZUCNSA-N

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Felix Stickel et al.
Archives of internal medicine, 165(16), 1835-1840 (2005-09-15)
Oxidative stress plays an important pathogenic role in hereditary hemochromatosis (HHC) and chronic hepatitis C virus infection (CHC). Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione S-transferase P1 (GSTP1) and manganese superoxide dismutase (MnSOD)
Sonia Jego et al.
Nature neuroscience, 16(11), 1637-1643 (2013-09-24)
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated
Shankar Sachidhanandam et al.
Nature neuroscience, 16(11), 1671-1677 (2013-10-08)
Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly understood. We trained mice to detect single brief whisker stimuli and report perceived stimuli by licking to obtain a reward. Pharmacological inactivation and optogenetic stimulation demonstrated a causal
Ihab Daou et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(47), 18631-18640 (2013-11-22)
We report a novel model in which remote activation of peripheral nociceptive pathways in transgenic mice is achieved optogenetically, without any external noxious stimulus or injury. Taking advantage of a binary genetic approach, we selectively targeted Nav1.8(+) sensory neurons for
Adam J Mead et al.
Blood, 121(20), 4156-4165 (2013-03-29)
The association between somatic JAK2 mutation and myeloproliferative neoplasms (MPNs) is now well established. However, because JAK2 mutations are associated with heterogeneous clinical phenotypes and often occur as secondary genetic events, some aspects of JAK2 mutation biology remain to be

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