01-5600

Sigma-Aldrich

Aniline

JIS special grade, ≥99.0%

Linear Formula:
C6H5NH2
CAS Number:
Molecular Weight:
93.13
Beilstein/REAXYS Number:
605631
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

grade

JIS special grade

vapor density

3.22 (185 °C, vs air)

vapor pressure

0.7 mmHg ( 25 °C)

assay

≥99.0%

form

liquid

autoignition temp.

1139 °F

expl. lim.

11 %

availability

available only in Japan

refractive index

n20/D 1.586 (lit.)

pH

8.8 (20 °C, 36 g/L)

bp

184 °C (lit.)

mp

−6 °C (lit.)

density

1.022 g/mL at 25 °C (lit.)

SMILES string

Nc1ccccc1

InChI

1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2

InChI key

PAYRUJLWNCNPSJ-UHFFFAOYSA-N

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Biochem/physiol Actions

The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Signal Word

Danger

Target Organs

Blood

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 1547 6.1 / PGII

WGK Germany

WGK 3

Flash Point(F)

158.0 °F - closed cup

Flash Point(C)

70 °C - closed cup

Hongli Ji et al.
Molecular plant-microbe interactions : MPMI, 28(5), 519-533 (2015-01-22)
The nonprotein amino acid β-aminobutyric acid (BABA) is known to protect plants against various pathogens. The mode of action is relatively diverse and specific in different plant-pathogen systems. To extend the analysis of the mode of action of BABA to...
M Peluso et al.
Carcinogenesis, 21(2), 183-187 (2000-02-05)
The 'Mediterranean diet', a diet rich in cereals, fruit and vegetables, has been associated with lowering the risk of a variety of cancers of the digestive tract and the bladder. In a previous study, we showed that the high phenolic...
J S Bus et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 25(8), 619-626 (1987-08-01)
Aniline and several structurally-related aromatic amines produce spleen tumours in rats given high doses of compound in 2-year bioassay studies. Evaluation of the pathogenesis of the splenic lesions and characterization of the disposition of radiolabelled aniline in animals suggests that...
Conghui Tang et al.
Journal of the American Chemical Society, 134(46), 18924-18927 (2012-11-08)
A novel and efficient copper-catalyzed azidation reaction of anilines via C-H activation has been developed. This method, in which the primary amine acts as a directing group by coordinating to the metal center, provides ortho azidation products regioselectively under mild...
Timo Stahl et al.
Journal of the American Chemical Society, 135(4), 1248-1251 (2013-01-15)
Heterolytic splitting of the Si-H bond mediated by a Ru-S bond forms a sulfur-stabilized silicon cation that is sufficiently electrophilic to abstract fluoride from CF(3) groups attached to selected anilines. The ability of the Ru-H complex, generated in the cooperative...

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