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04471

Supelco

(R)-(+)-α-Lipoic acid

analytical standard

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Synonym(s):
(R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥98.0% (HPLC)

optical activity

[α]/D +115±5°, c = 1% in ethanol

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

48-52 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CCCC[C@@H]1CCSS1

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

InChI key

AGBQKNBQESQNJD-SSDOTTSWSA-N

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This Item
07039T1395T5625
(R)-(+)-α-Lipoic acid analytical standard

Supelco

04471

(R)-(+)-α-Lipoic acid

-
(R)-(+)-α-Lipoic acid ≥98.0% (HPLC)

Sigma-Aldrich

07039

(R)-(+)-α-Lipoic acid

-
(±)-α-Lipoic acid BioReagent, suitable for cell culture, ≥99%

Sigma-Aldrich

T1395

(±)-α-Lipoic acid

Essential+ Grade
(±)-α-Lipoic acid synthetic, ≥99% (titration), powder

Sigma-Aldrich

T5625

(±)-α-Lipoic acid

-
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

application(s)

cleaning products
cosmetics
food and beverages
personal care

application(s)

-

application(s)

-

application(s)

-

format

neat

format

-

format

-

format

-

assay

≥98.0% (HPLC)

assay

≥98.0% (HPLC)

assay

≥99%

assay

≥99% (titration)

optical activity

[α]/D +115±5°, c = 1% in ethanol

optical activity

-

optical activity

-

optical activity

-

General description

α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.

Application

α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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25G
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α-Lipoic Acid α-Lipoic Acid, CAS 1077-28-7 is an oxidized form with antioxidant properties. Reduces renal lipid peroxidation in rats with cisplatin n-induced nephrotoxicity.

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Determination of free ?-lipoic acid in foodstuffs by HPLC coupled with CEAD and ESI-MS.
Durrani, et al.
Food Chemistry, 120(4), 1143-1148 (2010)
Determination of lipoic acid by flow-injection and high-performance liquid chromatography with chemiluminescence detection.
Wolyniec, et al.
Talanta, 96(2), 223-229 (2012)
High-performance liquid chromatographic assay for $\alpha$-lipoic acid and five of its metabolites in human plasma and urine.
Teichert, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 769(2), 269-281 (2002)
Determination of lipoic acid in human plasma by HPLC-ECD using liquid-liquid and solid-phase extraction: Method development, validation and optimization of experimental parameters.
Khan, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(28), 2782-2788 (2010)
W Witt et al.
Journal of chromatography. B, Biomedical sciences and applications, 705(1), 127-131 (1998-03-14)
A new method for the quantitation of lipoic acid in plasma and tissues based on the selective precolumn derivatization of thiols with the fluorescent label monobromobimane is described. After extraction with diethyl ether, the dithiolane ring of lipoic acid is

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