31593

Supelco

Arecoline hydrobromide

VETRANAL®, analytical standard

Synonym(s):
Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide, 1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide, Taeniolin, Arecaidine methyl ester hydrobromide, Methyl 1-methyl-1,2,5,6-tetrahydronicotinate hydrobromide
Empirical Formula (Hill Notation):
C8H13NO2 · HBr
CAS Number:
Molecular Weight:
236.11
Beilstein/REAXYS Number:
3914826
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

analytical standard

product line

VETRANAL®

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

172-176 °C (lit.)

Featured Industry

Clinical
Food and Beverages

format

neat

SMILES string

Br[H].COC(=O)C1=CCCN(C)C1

InChI

1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H

InChI key

AXOJRQLKMVSHHZ-UHFFFAOYSA-N

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General description

Arecoline hydrobromide is an arecoline salt of hydrobromic acid generally used in removing parasites from dog′s intestine. It has a strong parasympathomimetic action.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Arecoline hydrobromide may have been used as working standard in the determination of arecoline concentration from dog plasma using LC–MS/MS.

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

hazcat

Acute Tox. 4 Oral

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

THE RELATION BETWEEN METHOD OF ADMINISTRATION, ROUTE OF ABSORPTION, INHIBITORY ACTIONS AND ACUTE TOXICITY OF ARECOLINE HYDROBROMIDE IN DOGS.
FORBES LS.
Annals of Tropical Medicine and Parasitology, 58, 119-131 (1964)
Sarah L Withey et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 397-409 (2018-05-23)
Evidence suggests that the α4β2, but not the α7, subtype of the nicotinic acetylcholine receptor (nAChR) plays a key role in mediating the behavioral effects of nicotine and related drugs. However, the importance of other nAChR subtypes remains unclear. The...
Sid Ahmed Labed et al.
Immunity, 48(5), 963-978 (2018-05-17)
Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense against infection and to microbiota homeostasis. Understanding the mechanisms that regulate such expression is necessary for understanding immune homeostasis and inflammatory disease and for developing safe and effective...
Zhizhong Xu et al.
Neuroreport, 30(2), 134-138 (2018-12-21)
Cerebral demyelination is possibly one of the main pathological factors involved in the development of schizophrenia. Our previous studies have showed that Areca catechu nut extract could ameliorate cognitive decline by facilitating myelination processes in the frontal cortex in a...
Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry.
Li B
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 15;969, 12-18 (2014)

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