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31598

Supelco

4-Aminobiphenyl

analytical standard

Synonym(s):
4-Biphenylamine, 4-Aminodiphenyl, 4-Biphenylylamine, 4-Phenylaniline, Xenylamine, Biphenyl-4-ylamine, NSC 7660
Linear Formula:
C6H5C6H4NH2
CAS Number:
Molecular Weight:
169.22
Beilstein:
386533
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

autoignition temp.

842 °F

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

191 °C/15 mmHg (lit.)

mp

52-54 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

Nc1ccc(cc1)-c2ccccc2

InChI

1S/C12H11N/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,13H2

InChI key

DMVOXQPQNTYEKQ-UHFFFAOYSA-N

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General description

4-Aminobiphenyl is classified under the aromatic amine group of compounds.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
4-Aminobiphenyl has been used as an analytical reference standard for the analysis of 4-aminobiphenyl in food packaging materials by liquid chromatography-full scan-high resolution mass spectrometry (LC-HRMS).
It may be used as an analytical reference standard for the determination of 4-aminobiphenyl in:
  • Particulate phase mainstream cigarette smoke samples by solid-phase extraction (SPE) and gas chromatography coupled to MS equipped with selected ion monitoring (SIM) mode of detection as well as simultaneous distillation and extraction (SDE) and GC-MS with SIM detection.
  • Environmental water samples by hollow fiber-liquid phase microextraction (HF-LPME) and microemulsion electrokinetic chromatography (MEEKC).
  • Indoor and outdoor air samples by GC-MS.

Pictograms

Exclamation markHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1A

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Analysis of polycyclic aromatic hydrocarbons, phenols and aromatic amines in particulate phase cigarette smoke using simultaneous distillation and extraction as a sole sample clean-up step.
Forehand JB, et al.
Journal of Chromatography A, 898(1), 111-124 (2000)
Simultaneous determination of aliphatic and aromatic amines in indoor and outdoor air samples by gas chromatography-mass spectrometry.
Akyuz M.
Talanta, 71(1), 486-492 (2007)
Determination of aromatic amines in environmental water sample by hollow fiber-liquid phase microextraction and microemulsion electrokinetic chromatography.
Lin Z, et al.
Journal of Chromatography A, 1217(26), 4507-4510 (2010)
Moinuddin et al.
Environmental toxicology, 29(5), 568-576 (2012-05-23)
4-Aminobiphenyl (4-ABP), an aromatic amine is a major environmental carcinogen found mainly in cigarette smoke. It has been vastly implicated in mutagenesis and cancer development. In this study, commercially available human placental DNA was exposed to 4-ABP (1.3 mM) in
Samuel M Cohen et al.
Critical reviews in toxicology, 36(10), 803-819 (2006-11-23)
The IPCS Human Relevance Framework was evaluated for a DNA-reactive (genotoxic) carcinogen, 4-aminobiphenyl, based on a wealth of data in animals and humans. The mode of action involves metabolic activation by N-hydroxylation, followed by N-esterification leading to the formation of

Protocols

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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