76078

SAFC

L-Methionine sulfoximine

PharmaGrade, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.

Synonym(s):
L-S-(3-Amino-3-carboxypropyl)-S-methylsulfoximine
Linear Formula:
CH3S(O)(=NH)CH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
180.23
Beilstein/REAXYS Number:
6175446
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

biological source

synthetic

Agency/Method

non-compendial

product line

PharmaGrade

assay

≥96% (rel., HPLC)
95-102% (w/w) (HPLC)

form

solid

optical activity

[α]20/D +10.8 to +14.0°, c = 1 in H2O

impurities

≤0.1% each single unknown impurity (rel.)
≤0.5% sulfated ash
≤0.5% water (Karl Fischer)
≤1% methionine sulfone (rel.)
≤1% methionine sulfoxide (rel.)
≤10 mg/kg azide
≤2% methionine (rel.)
≤5000 ppm ethanol (GC-HS)

mp

>210 °C (dec.) (lit.)

suitability

complies for H-NMR
complies for identity (HPLC)

SMILES string

CS(=N)(=O)CC[C@H](N)C(O)=O

InChI

1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1

InChI key

SXTAYKAGBXMACB-DPVSGNNYSA-N

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General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Ji Wang et al.
PloS one, 6(3), e18233-e18233 (2011-04-13)
The membrane-proximal external region (MPER) of the HIV-1 gp41 consists of epitopes for the broadly cross-neutralizing monoclonal antibodies 2F5 and 4E10. However, antigens containing the linear sequence of these epitopes are unable to elicit potent and broad neutralizing antibody responses...
Hsiu-Ni Kung et al.
PLoS genetics, 7(8), e1002229-e1002229 (2011-08-20)
Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements. While many cancer cells depend on exogenous glutamine for survival to justify...
Evan T Brower et al.
Biochemistry, 48(4), 779-785 (2009-01-28)
The initial events of HIV-1 cell infection involve the sequential binding of the viral envelope glycoprotein gp120 to the cellular CD4 receptor and the coreceptor, usually CCR5 or CXCR4. Binding to the coreceptor triggers the chain of events that culminates...
Marilynn A Larson et al.
The Biochemical journal, 462(2), 329-335 (2014-06-12)
Human BChE (butyrylcholinesterase) protects against the toxicity of organophosphorus nerve agents and pesticides. BChE purified from human plasma is limited and pathogen carry-over is a concern. Unlike the native BChE tetrameric complex with a residence time of days, rBChE (recombinant...
Aneesh Vijayan et al.
PloS one, 10(7), e0133595-e0133595 (2015-07-25)
In the HIV vaccine field, there is a need to produce highly immunogenic forms of the Env protein with the capacity to trigger broad B and T-cell responses. Here, we report the generation and characterization of a chimeric HIV-1 gp120...
Protocols
LC/MS Analysis of L-Methionine Sulfoximine and Sulfone on Ascentis<sup>®</sup> Express OH5
Read More
Separation of L-Methionine sulfone; L-Methionine sulfoximine; L-Methionine sulfoxide
Read More

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