D6750

Sigma-Aldrich

Sodium deoxycholate

≥97% (titration)

Synonym(s):
Desoxycholic acid sodium salt, 3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt
Empirical Formula (Hill Notation):
C24H39NaO4
CAS Number:
Molecular Weight:
414.55
Beilstein/REAXYS Number:
3581950
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

biological source

bovine bile

Quality Level

description

anionic

assay

≥97% (titration)

form

powder

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

CMC

2-6 mM (20-25°C)

HLB

16

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

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General description

Sodium deoxycholate is a bile salt and an ionic detergent. Bile salts work along with lipids/fats/cholesterol and form mixed micelles in the intestine. These micelles help in fat digestion and absorption through the intestinal wall.

Application

Sodium deoxycholate has been used in the lysis buffer prepared for brown adipose tissue. It has been used in the decellularization of aortic valvular conduit.

Packaging

10, 25, 100, 500 g in poly bottle

Biochem/physiol Actions

Solubilizes fats for absorption in the intestines.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Methods in Cell Biology (1974)
Chemistry and biology of bile acids.
Mukhopadhyay S and Maitra U
Current Science, 87, 1666-1683 (2004)
Development of decellularized aortic valvular conduit coated by heparin-SDF-1a multilayer.
Zhou J et al.
The Annals of Thoracic Surgery, 99, 612-612 (2015)
L L Liu et al.
Oncogene, 33(24), 3140-3150 (2013-07-16)
Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most...
Shin Yoshimoto et al.
Nature, 499(7456), 97-101 (2013-06-28)
Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating...
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