PHR1730

Supelco

Bupropion Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
(±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride, Bupropion hydrochloride
Empirical Formula (Hill Notation):
C13H18ClNO · HCl
CAS Number:
Molecular Weight:
276.20
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 1 g

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1078733

SMILES string

Cl[H].CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

InChI

1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

InChI key

HEYVINCGKDONRU-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530), SLC6A3(6531)

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General description

Bupropion Hydrochloride is an aminoketone derivative and an antidepressant drug, widely used to treat depression. It is also employed for the treatment of obesity, smoking cessation and attention deficit hyperactivity disorder.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Bupropion Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and electroanalytical technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3044 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
HPLC assay for bupropion and its major metabolites in human plasma.
Loboz K K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 823(2), 115-121 (2005)
The determination of bupropion hydrochloride in pharmaceutical dosage forms by original UV and second derivative UV spectrophotometry, potentiometric and conductometric methods
Yeniceli D and Dogrukal AKD
Turkish Journal of Pharmaceutical Sciences, 7, 99-110 (2010)

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