T1320

Sigma-Aldrich

2′,4′,5′,7′-Tetrabromorhodamine 123 bromide

Empirical Formula (Hill Notation):
C21H13Br5N2O3
Molecular Weight:
740.86
MDL number:

mol wt

740.87

solubility

DMF: soluble
methanol: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

Br.COC(=O)c1ccccc1C2=C3C=C(Br)C(=N)C(Br)=C3Oc4c(Br)c(N)c(Br)cc24

Biochem/physiol Actions

Can be induced to produce singlet oxygen targeted to mitochondria. Singlet oxygen generation quantum yield is reported to be 0.65-0.70.

Certificate of Analysis

Certificate of Origin

J R Bunting
Photochemistry and photobiology, 55(1), 81-87 (1992-01-01)
Aromatic cationic dyes have a potential as photo-chemotherapeutic agents because they are selectively concentrated into the mitochondria of cancerous cells. The mechanism of cytophototoxicity has been proposed to be primarily due to dye sensitized photogeneration of highly toxic singlet oxygen...

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