≥95.0% (GC)

Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
PubChem Substance ID:


≥95.0% (GC)

optical activity

[α]25/D −55.1°, c = 0.034% in chloroform


236 °C (lit.)

storage temp.


SMILES string




InChI key


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Senecionine has been used in a study to observe the gender-dependent difference of glutathione antioxidant system and its influence on hepatotoxic pyrrolizidine alkaloid isoline-induced liver injury. Senecionine has also been used in a study to observe a new metabolic pathway for pyrrolizidine alkaloids.


Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 17806.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.


Skull and crossbones

Signal Word


Hazard Statements


Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral


6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

I Narberhaus et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 173(6), 483-491 (2003-06-13)
Several Longitarsus flea beetle species sequester pyrrolizidine alkaloids acquired from their Asteraceae and Boraginaceae host plants. We carried out feeding and injection experiments using radioactively labeled pyrrolizidine alkaloids to investigate the physiological mechanisms of uptake, metabolism and storage of alkaloids...
Yu-Qi He et al.
Chemical research in toxicology, 23(3), 591-599 (2010-01-23)
Pyrrolizidine alkaloids (PAs) possess significant hepatotoxicity to humans and animals after metabolic activation by liver P450 enzymes. Metabolism pathways of PAs have been studied for several decades, including metabolic activation, hydroxylation, N-oxidation, and hydrolysis. However, the glucuronidation of intact PAs...
Annika Reinhard et al.
Journal of chemical ecology, 35(9), 1086-1095 (2009-09-25)
Recent studies have shown the occurrence of plant derived pyrrolizidine alkaloids (PAs) in retail honeys and pollen loads, but little is known about how these compounds influence the fitness of foraging honey bees. In feeding experiments, we tested a mix...
T Langer et al.
Planta medica, 62(3), 267-271 (1996-06-01)
We developed an immunoassay with antibodies against retrorsine to detect the closely related senecionine, the main alkaloid in various Asteraceae. Sensitivity is about 23 pg (68 fmol) for senecionine. Cross reactivity of monocrotalin, retrorsine N-oxide, senkirkine (< 0.1%), and seneciphylline...
W G Chung et al.
Xenobiotica; the fate of foreign compounds in biological systems, 25(9), 929-939 (1995-09-01)
1. We have purified three P450s from the liver of the phenobarbital (PB)-treated guinea pig in order to evaluate the role of these enzymes in pyrrolizidine alkaloid (PA) metabolism. 2. PB treatment of guinea pig increased the hepatic microsomal conversion...

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