21965

Sigma-Aldrich

5(6)-Carboxy-X-rhodamine

BioReagent, suitable for fluorescence

Empirical Formula (Hill Notation):
C33H30N2O5
CAS Number:
Molecular Weight:
534.60
PubChem Substance ID:
NACRES:
NA.32

Quality Level

product line

BioReagent

mp

≥250 °C (lit.)

fluorescence

λex 570 nm; λem ~595 nm in 0.1 M Tris pH 8.0

suitability

suitable for fluorescence

SMILES string

OC(=O)c1ccc2c(c1)C(=O)OC23c4cc5CCCN6CCCc(c4Oc7c8CCCN9CCCc(cc37)c89)c56.OC(=O)c%10ccc%11C(=O)OC%12(c%13cc%14CCCN%15CCCc(c%13Oc%16c%17CCCN%18CCCc(cc%12%16)c%17%18)c%14%15)c%11c%10

InChI

1S/2C33H30N2O5/c36-31(37)20-9-10-24-23(15-20)32(38)40-33(24)25-16-18-5-1-11-34-13-3-7-21(27(18)34)29(25)39-30-22-8-4-14-35-12-2-6-19(28(22)35)17-26(30)33;36-31(37)20-9-10-21-24(17-20)33(40-32(21)38)25-15-18-5-1-11-34-13-3-7-22(27(18)34)29(25)39-30-23-8-4-14-35-12-2-6-19(28(23)35)16-26(30)33/h2*9-10,15-17H,1-8,11-14H2,(H,36,37)

InChI key

KLNOCCPJAOCRHF-UHFFFAOYSA-N

Application

5(6)-Carboxy-X-rhodamine may be used as a fluorescent dye in nucleic acid analytical research applications.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

partially soluble in methanol, 0.1 M Tris pH 8.0

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

hazcat

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Jin-Oh You et al.
International journal of nanomedicine, 1(2), 173-180 (2007-08-29)
Reverse microemulsion was used as a template to fabricate chitosan-alginate core-shell nanoparticles encapsulated with enhanced green fluorescent protein (EGFP)-encoded plasmids. The average size of DNA-entrapped nanoparticles measured by dynamic light scattering was increased proportionally, with the N/P ratios ranging from...
Gadi Cohen et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1602-1613 (2019-06-14)
The early embryo implantation is characterized by enhanced uterine vascular permeability at the site of blastocyst attachment, followed by extracellular-matrix remodeling and angiogenesis. Two TG (transglutaminase) isoenzymes, TG2 (tissue TG) and FXIII (factor XIII), catalyze covalent cross-linking of the extracellular-matrix....
Jun Wang et al.
Clinical chemistry, 56(4), 623-632 (2010-03-09)
The EGFR [epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)] gene is known to harbor genomic alterations in advanced lung cancer involving gene amplification and kinase mutations that predict the clinical response to EGFR-targeted inhibitors. Methods for...
Silvia Mannucci et al.
International journal of nanomedicine, 15, 1745-1758 (2020-03-28)
Solid lipid nanoparticles are largely used in biomedical research and are characterized by high stability and biocompatibility and are also able to improve the stability of various loaded molecules. In vitro studies demonstrated that these nanoparticles are low cytotoxic, while...
Tae Seok Seo et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(17), 5926-5931 (2005-04-15)
We report four-color DNA sequencing by synthesis (SBS) on a chip, using four photocleavable fluorescent nucleotide analogues (dGTP-PC-Bodipy-FL-510, dUTP-PC-R6G, dATP-PC-ROX, and dCTP-PC-Bodipy-650) (PC, photocleavable; Bodipy, 4,4-difluoro-4-bora-3alpha,4alpha-diaza-s-indacene; ROX, 6-carboxy-X-rhodamine; R6G, 6-carboxyrhodamine-6G). Each nucleotide analogue consists of a different fluorophore attached to...
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