30434

Sigma-Aldrich

Dansylhydrazine

BioReagent, suitable for fluorescence, ≥90% (HPLC)

Synonym(s):
5-(Dimethylamino)-1-naphthalenesulfonic hydrazide, 5-(Dimethylamino)naphthalene-1-sulfono­hydra­zide, Dns-Hz
Linear Formula:
(CH3)2NC10H6SO2NHNH2
CAS Number:
Molecular Weight:
265.33
Beilstein/REAXYS Number:
2868662
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32
Pricing and availability is not currently available.

product line

BioReagent

assay

≥90% (HPLC)

mp

126-130 °C (lit.)

solubility

ethanol: soluble

fluorescence

λex 340 nm; λem 525 nm in ethanol

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)NN

InChI

1S/C12H15N3O2S/c1-15(2)11-7-3-6-10-9(11)5-4-8-12(10)18(16,17)14-13/h3-8,14H,13H2,1-2H3

InChI key

KPQYDVAFRDWIBW-UHFFFAOYSA-N

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Application

Dansylhydrazine (DH) is widely used as a fluorometric reagent for carbonyl compounds. Dansylated carbonyl molecules can be separated and identified by analytical techniques.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Fluorescent marker for carbonyl compounds

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36/37

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
1-Dimethylaminonaphthalene-5-sulfonyl hydrazine (dansyl hydrazine): a fluorometric reagent for carbonyl compounds.
R Chayes et al.
Analytical biochemistry, 42(1), 283-286 (1971-07-01)
J M Anderson
Analytical biochemistry, 152(1), 146-153 (1986-01-01)
Methods for the determination of carbonyl compounds of biological origin by high-performance liquid chromatography were improved by the use of new fluorescent derivatizing agents. Eight fluorescent hydrazides were either synthesized or obtained commercially and compared to dansyl hydrazine (1-dimethylaminonaphthalene-5-sulfonylohydrazide). Four...
Heather L Lord et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(13), 1292-1298 (2009-01-07)
Analytical derivatization (AD) increases the sensitivity of analysis by one to three orders of magnitude, stabilizes labile analytes and converts them into readily extractable products. Using a variant of this technique, we applied solid phase analytical derivatization (SPAD) to fully...
Osama Y Al-Dirbashi et al.
Biomedical chromatography : BMC, 22(11), 1181-1185 (2008-07-25)
We describe an improved diagnostic method for tyrosinemia type 1 based on quantifying succinylacetone in dried blood spots by ultra-performance liquid chromatography tandem mass spectrometry. Succinylacetone extracted from a single 3/16 inch disk of specimen collection paper containing a dried...
Cheuk Fai Chiu et al.
The journal of physical chemistry. A, 115(34), 9579-9584 (2011-07-20)
The development of chromophore-carbon nanotube hybrids requires efficient and accurate methods to investigate their photophysical properties. Using the ability of the fluorescence labeling of surface species (FLOSS) technique to determine the density of covalently attached dyes to the surface of...

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