43608

Sigma-Aldrich

3,3′-Dipropylthiadicarbocyanine iodide

suitable for fluorescence, ≥98.0% (TLC)

Synonym(s):
DiSC3(5), 3-Propyl-2-5-3-propyl-2(3H)-benzothiazolylidene-1,3-pentadienylbenzothiazolium iodide
Empirical Formula (Hill Notation):
C25H27IN2S2
CAS Number:
Molecular Weight:
546.53
MDL number:
PubChem Substance ID:
NACRES:
NA.32
Pricing and availability is not currently available.

Quality Level

assay

≥98.0% (TLC)

mp

245 °C (dec.) (lit.)

solubility

DMF: soluble

fluorescence

λex 500 nm; λem 705 nm in DMF

suitability

suitable for fluorescence

SMILES string

I-.CCCN1C(\Sc2ccccc12)=C\C=C\C=C\c3sc4ccccc4n+3CCC

InChI

1S/C25H27N2S2.HI/c1-3-18-26-20-12-8-10-14-22(20)28-24(26)16-6-5-7-17-25-27(19-4-2)21-13-9-11-15-23(21)29-25;/h5-17H,3-4,18-19H2,1-2H3;1H/q+1;/p-1

InChI key

GDEURKKLNUGTDA-UHFFFAOYSA-M

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Application

3,3′-Dipropylthiadicarbocyanine iodide DiSC3(5) is used as a fluorogenic probe to detect and measure changes in transmembrane potential or configuration induced by membrane altering agents.

Packaging

100 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Transmembrane potential measurements

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Marie Markones et al.
Biophysical journal, 118(2), 294-302 (2019-12-18)
Membrane proteins are embedded in a complex lipid environment that influences their structure and function. One key feature of nearly all biological membranes is a distinct lipid asymmetry. However, the influence of membrane asymmetry on proteins is poorly understood, and...
Ines Greco et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-25)
Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging health problem for companion animals in veterinary medicine. Therefore, discovery of novel antimicrobial agents for treatment of Staphylococcus-associated canine infections is urgently needed to reduce use of human antibiotics in veterinary medicine. In...
Sonya E Neal et al.
Molecular biology of the cell, 28(21), 2773-2785 (2017-08-18)
Prokaryotes have aerobic and anaerobic electron acceptors for oxidative folding of periplasmic proteins. The mitochondrial intermembrane space has an analogous pathway with the oxidoreductase Mia40 and sulfhydryl oxidase Erv1, termed the mitochondrial intermembrane space assembly (MIA) pathway. The aerobic electron...
Ines Greco et al.
Scientific reports, 9(1), 3679-3679 (2019-03-08)
Integumentary infections like pyoderma represent the main reason for antimicrobial prescription in dogs. Staphylococcus pseudintermedius and Pseudomonas aeruginosa are frequently identified in these infections, and both bacteria are challenging to combat due to resistance. To avoid use of important human...
Michael J Ellis et al.
Nature communications, 10(1), 197-197 (2019-01-16)
Salmonella Typhimurium (S. Tm) establishes systemic infection in susceptible hosts by evading the innate immune response and replicating within host phagocytes. Here, we sought to identify inhibitors of intracellular S. Tm replication by conducting parallel chemical screens against S. Tm...
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