4-Methylumbelliferyl 4-guanidinobenzoate hydrochloride hydrate

≥85% (HPLC)

4-Guanidinobenzoic acid 4-methylumbelliferyl ester hydrochloride, MUGB
Empirical Formula (Hill Notation):
C18H15N3O4 · HCl · xH2O
CAS Number:
Molecular Weight:
373.79 (anhydrous basis)
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.


≥85% (HPLC)




λex 323 nm; λem 464 nm (solvent pH 6.0)
λex 360 nm; λem 449 nm (Reaction Product)

storage temp.


SMILES string




InChI key


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Other Notes

Fluorimetric titrant for α- and β-trypsin, thrombin and Factor Xa

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dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Certificate of Analysis
Certificate of Origin
Some sensitive methods for the assay of trypsinlike enzymes.
P L Coleman et al.
Methods in enzymology, 45, 12-26 (1976-01-01)
G W Jameson et al.
The Biochemical journal, 131(1), 107-117 (1973-01-01)
Several esters of 4-methylumbelliferone and 2-naphthol were synthesized and examined as possible spectrofluorimetric titrants for bovine alpha-chymotrypsin, trypsin, thrombin, Factor Xa and for subtilisin Novo. 4-Methylumbelliferyl p-guanidinobenzoate hydrochloride (MUGB) is a satisfactory titrant for alpha- and beta-trypsin, thrombin and Factor...
Lambro A Johnson et al.
Analytical biochemistry, 608, 113907-113907 (2020-08-20)
Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for thrombin. The coupled reactions result in accelerating p-nitroaniline (pNA) production...
J Grandoni et al.
Haemophilia : the official journal of the World Federation of Hemophilia, 23(2), 300-308 (2016-12-21)
LR769 is a new second-generation recombinant human Factor VIIa (rhFVIIa) developed for haemophilia treatment. We determined enzymatic properties of LR769 and its interaction with antithrombin, tissue factor, platelets and endothelial protein C receptor (EPCR), compared with NovoSevenRT. Kinetic enzyme assays...
Simon J de Veer et al.
The Biochemical journal, 469(2), 243-253 (2015-05-20)
Laskowski inhibitors regulate serine proteases by an intriguing mode of action that involves deceiving the protease into synthesizing a peptide bond. Studies exploring naturally occurring Laskowski inhibitors have uncovered several structural features that convey the inhibitor's resistance to hydrolysis and...

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