69125

Sigma-Aldrich

Resorufin methyl ether

suitable for fluorescence, ≥98.0% (HPLC)

Synonym(s):
Methoxyresorufin, 7-Methoxy-3H-phenoxazin-3-one, O7-Methylresorufin
Empirical Formula (Hill Notation):
C13H9NO3
CAS Number:
Molecular Weight:
227.22
Beilstein/REAXYS Number:
209529
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

assay

≥98.0% (HPLC)

mp

≥220 °C (lit.)

solubility

DMF: soluble
DMSO: soluble
alcohols: soluble

fluorescence

λex 571 nm; λem 585 nm in dealkylase(lit.)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

COc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3

InChI key

KNYYMGDYROYBRE-UHFFFAOYSA-N

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Application

Used to differentiate isozymes of cytochrome P-450

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
A G Krainev et al.
Archives of biochemistry and biophysics, 298(1), 198-203 (1992-10-01)
Some eukaryotic cytochromes P450 (P450s) have a series of ionic amino acids, corresponding to Lys250, Arg251, and Lys253 residues in the P450 1A2 sequence. To understand the roles of those ionic amino acids in the catalytic function of P450, three...
A Toby A Jenkins et al.
Bioelectrochemistry (Amsterdam, Netherlands), 68(1), 67-71 (2005-06-07)
This paper describes the utilisation of methoxy-resorufin ether as an electrochemical probe for studying cytochrome P450 CYP6G1. Methoxy-resorufin ether is well established as a versatile substrate for cytochrome P450, as its demethylated product, resorufin, is a fluorophore. We show that...
D F Staskal et al.
Toxicological sciences : an official journal of the Society of Toxicology, 84(2), 225-231 (2005-01-22)
Dioxins have been shown to bind and induce rodent CYP1A2, producing a dose-dependent hepatic sequestration in vivo. The induction of CYP1A2 activity has been used as a noninvasive biomarker for human exposure to dioxins; while there is a consistent relationship...
Nicholas E Hadjokas et al.
British journal of pharmacology, 136(3), 347-352 (2002-05-25)
1. Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity. Molecular...
Yune-Fang Ueng et al.
The Journal of pharmacy and pharmacology, 57(2), 227-232 (2005-02-22)
Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa. The cytochrome P450 (CYP) 1A2 substrate, theophylline, is an important therapeutic agent for the treatment of asthma, but has a narrow therapeutic index. To evaluate the pharmacokinetic...

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