A0779

Sigma-Aldrich

p-Aminoclonidine hydrochloride

solid

Synonym(s):
Apraclonidine hydrochloride, 2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride
Empirical Formula (Hill Notation):
C9H10Cl2N4 · xHCl
Molecular Weight:
245.11 (free base basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

form

solid

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C)
boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C)
0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C)
methanol: soluble (Solutions may be stored for several days at 4 °C)

storage temp.

2-8°C

SMILES string

ClH.Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1

InChI

1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

InChI key

OTQYGBJVDRBCHC-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Packaging

1 mg in glass bottle

Biochem/physiol Actions

α2-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T

Risk Statement

23/24/25

Safety Statement

22-36/37/39-45

RIDADR

UN 2811 6.1 / PGI

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
T Salminen et al.
The Journal of biological chemistry, 274(33), 23405-23413 (1999-08-07)
We have compared bacteriorhodopsin-based (alpha(2A)-AR(BR)) and rhodopsin-based (alpha(2A)-AR(R)) models of the human alpha(2A)-adrenengic receptor (alpha(2A)-AR) using both docking simulations and experimental receptor alkylation studies with chloroethylclonidine and 2-aminoethyl methanethiosulfonate hydrobromide. The results indicate that the alpha(2A)-AR(R) model provides a better...
J Cepelík et al.
Physiological research, 46(3), 203-208 (1997-01-01)
The effects of the selective alpha2-adrenergic agonist p-aminoclonidine, the nonselective adrenergic agonist epinephrine, the selective beta2-adrenergic agonist fenoterol and the adenosine A1 agonist R-PIA on intraocular pressure were studied in control and pertussis toxin-pretreated rabbits. Pretreatment of rabbits with pertussis...
M E Alburges et al.
Brain research bulletin, 32(2), 97-102 (1993-01-01)
The localization of alpha 2-receptors was determined by quantitative autoradiography using [125I]para-iodoclonidine ([125I]PIC) and [3H]para-aminoclonidine ([3H]PAC). In cortical tissue, [125I]PIC and [3H]PAC were equipotent in their capacity to bind sites recognized by oxymetazoline (preferentially binds to the alpha 2A receptor...
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