A3355

Sigma-Aldrich

ATC0175

≥98% (HPLC), solid

Synonym(s):
N-(cis-4-{4-(Dimethylamino)quinazolin-2-ylamino}cyclohexyl)-3,4-difluorobenzamide HCl
Empirical Formula (Hill Notation):
C23H26ClF2N5O
CAS Number:
Molecular Weight:
461.94
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 5 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

ClH.CN(C)c1nc(NC@@H2CCC@@H(CC2)NC(=O)c3ccc(F)c(F)c3)nc4ccccc14

InChI

1S/C23H25F2N5O.ClH/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14;/h3-7,12-13,15-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29);1H/t15-,16+;

InChI key

HUUPKFUYSQNNLO-FAESNJTISA-N

Packaging

10 mg in glass bottle

Biochem/physiol Actions

Non-peptide, orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.
ATC0175 is a non-peptide, orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.

Features and Benefits

This compound is featured on the Melanin-Concentrating Hormone Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Shigeyuki Chaki et al.
The Journal of pharmacology and experimental therapeutics, 313(2), 831-839 (2005-01-29)
Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral hypothalamus. It has been implicated in a number of physiological processes including feeding behavior, energy balance, and the regulation of emotional states. Here, we report in vitro and in...

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