A8013

Sigma-Aldrich

L-Arginase from bovine liver

lyophilized powder, 150-250 units/mg protein

Synonym(s):
L-Arginine amidinase, L-Arginine amidino-hydrolase
CAS Number:
Enzyme Commission number:
EC Number:
MDL number:
Pricing and availability is not currently available.

form

lyophilized powder

specific activity

150-250 units/mg protein

composition

Protein, ≥70% biuret

storage temp.

−20°C

Gene Information

cow ... ARG2(518752)

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Biochem/physiol Actions

L-Arginase is the major degradative enzyme for arginine; converts arginine to ornithine; deficiency is associated with spasticity and motor dysfunction.

Unit Definition

One unit will convert 1.0 μmole of L-arginine to ornithine and urea per min at pH 9.5 at 37 °C.

Physical form

Lyophilized powder containing manganous sulfate and sodium maleate.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

J L Boucher et al.
Cellular and molecular life sciences : CMLS, 55(8-9), 1015-1028 (1999-09-15)
Nitric oxide (NO) is a recently discovered mediator produced by mammalian cells. It plays a key role in neurotransmission, control of blood pressure, and cellular defense mechanisms. Nitric oxide synthases (NOSs) catalyze the oxidation of L-arginine to NO and L-citrulline....
Salimuddin et al.
The American journal of physiology, 277(1 Pt 1), E110-E117 (1999-07-17)
Arginase exists in two isoforms, the hepatic (arginase I) and extrahepatic types (arginase II). Arginase I is markedly induced in rat peritoneal macrophages and rat tissues in vivo by bacterial lipopolysaccharide (LPS). In contrast, both arginase I and arginase II...
M C Bewley et al.
Structure (London, England : 1993), 7(4), 435-448 (1999-04-10)
Arginase is a manganese-dependent enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. In ureotelic animals arginase is the final enzyme of the urea cycle, but in many species it has a wider role controlling the use of...
Abhishek Srivastava et al.
Biochemistry, 52(3), 508-519 (2012-12-29)
Urea producing bimetallic arginases are essential for the synthesis of polyamine, DNA, and RNA. Despite conservation of the signature motifs in all arginases, a nonconserved ¹⁵³ESEEKAWQKLCSL¹⁶⁵ motif is found in the Helicobacter pylori enzyme, whose role is yet unknown. Using...
Shelley B Weisser et al.
Methods in molecular biology (Clifton, N.J.), 946, 225-239 (2012-11-28)
Macrophages play a key role in the innate immune response and help to direct the acquired immune response. Early in the innate immune response, they produce reactive oxygen species and pro-inflammatory cytokines and chemokines to drive inflammation and are referred...

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