A9354

Sigma-Aldrich

Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(DABCYL)-Arg-OH trifluoroacetate salt

≥95% (HPLC), powder

Synonym(s):
Ac-RE(EDANS)-VHHQKLVF-K(DABCYL)-R-OH
Empirical Formula (Hill Notation):
C100H144N30O20S · xC2HF3O2
Molecular Weight:
2118.47 (free base basis)
MDL number:
NACRES:
NA.77

Quality Level

assay

≥95% (HPLC)

form

powder

storage condition

desiccated
protect from light
under inert gas

color

red to purple

shipped in

wet ice

storage temp.

−20°C

Amino Acid Sequence

Ac-Arg-Glu-EDANS-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys-DABCYL-Arg

Biochem/physiol Actions

α-Secretase substrate II, fluorogenic.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

H Komano et al.
The Journal of biological chemistry, 273(48), 31648-31651 (1998-11-21)
Human beta-amyloid precursor protein (APP) introduced into yeast undergoes alpha-secretase-type cleavage, suggesting that yeast have alpha-secretase-like protease(s). Here we report that two structurally and functionally related glycosyl-phosphatidylinositol-linked yeast aspartyl proteases, Mkc7p and Yap3p (collectively termed yapsin), are responsible for alpha-secretase-type...

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