Krueppel-like factor 4, KLF4, is believed to be an stem cell marker for both embryonic stem cells and mesenchymal stem cells. KLF4 can initiate transcription of a variety of genes including PFKP and is considered a tumor suppressor gene.
Synthetic peptide directed towards the N terminal region of human KLF4
The mammalian Kruppel-like transcription factor, KLF4 is involved in preventing centrosome amplification following DNA damage caused by gamma-irradiation. It is both necessary and sufficient in preventing centrosome amplification following gamma-radiation-induced DNA damage and does so by transcriptionally suppressing cyclin E expression n. Kruppel-like factor 4 is also known to exhibit checkpoint function during the G1/S and G2/M transitions of the cell cycle.
Synthetic peptide located within the following region: GAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSAS
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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