G protein-coupled receptor 177 (Evi/Gpr177), a Wnt trafficking regulator, is a multipass transmembrane protein that regulates the sorting and secretion of Wnt protein. Evi/Gpr177 is required for organogenesis during embryogenesis and for the establishment of the anterior-posterior axis. Evi/Gpr177 promotes various cancers such as glioma tumourigenesis.
Anti-GPR177 polyclonal antibody reacts with bovine, rat, human, mouse, and canine G protein-coupled receptor 177 proteins.
The immunogen for anti-GPR177 antibody: synthetic peptide derected towards the N terminal of human GPR177
Anti-GPR177 polyclonal antibody is used to tag glutathione G protein-coupled receptor 177 protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to study the role of G protein-coupled receptor 177 in Wnt signaling, embryogenesis and cancer progression.
Synthetic peptide located within the following region: ARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHME
Lyophilized from PBS buffer with 2% sucrose
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