Perforin (PRF1, PFN1) is a protein that can form transmembrane tubules and mediate cell lysis. PFN1 mutations have been linked to amyotrophic lateral sclerosis, frontotemporal dementia and amilial hemophagocytic lymphohistiocytosis type 2 (HPLH2).
Rabbit Anti-PFN1 antibody recognizes human, mouse, rat, pig, and bovine PFN1.
Synthetic peptide directed towards the N terminal region of human PFN1
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Rabbit Anti-PFN1 antibody is suitable for western blot applications at a concentration of 1μg/ml.
PFN1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Synthetic peptide located within the following region: AGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVL
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.