MilliporeSigma
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B1187

Sigma-Aldrich

Anti-BMPR2 (631-645) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):
Anti-BMPR3, Anti-BMPRII, Anti-BMR2, Anti-BRK3, Anti-Bone morphogenetic protein receptor type II precursor (Homo sapiens), Anti-PPH1, Anti-TALK, Anti-TRG10
MDL number:

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~115 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... BMPR2(659)

General description

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage, hematopoietic cell formation and mesoderm patterning. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors.

Immunogen

synthetic peptide corresponding to amino acids 631-645 of human BMPR2.

Application

Anti-BMPR2 (631-645) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Bone Morphogenetic Protein Receptor 2 (BMPR2) is a 70-80kDa protein that belongs to serine/threonine kinases family. BMPs bind to BMPR2 and then recruit the transducing type I receptor which in turn activates the Smad protein signalling pathway. BMPR2 also plays an essential role in human T-cell differentiation. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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