Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage, hematopoietic cell formation and mesoderm patterning. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors.
synthetic peptide corresponding to amino acids 631-645 of human BMPR2.
Anti-BMPR2 (631-645) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Bone Morphogenetic Protein Receptor 2 (BMPR2) is a 70-80kDa protein that belongs to serine/threonine kinases family. BMPs bind to BMPR2 and then recruit the transducing type I receptor which in turn activates the Smad protein signalling pathway. BMPR2 also plays an essential role in human T-cell differentiation. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH).
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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