B-HT 933 dihydrochloride

≥98% (HPLC), solid

Azepexole dihydrochloride, 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride
Empirical Formula (Hill Notation):
C9H15N3O · 2HCl
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.


≥98% (HPLC)




white to off-white


H2O: >20 mg/mL

SMILES string




InChI key


Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Selective α2-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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dust mask type N95 (US),Eyeshields,Gloves


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WGK Germany


Certificate of Analysis
Certificate of Origin
G Lembo et al.
The Journal of clinical investigation, 100(8), 2007-2014 (1997-10-23)
We explored in 51 normal subjects, distributed in various series of experiments, whether endothelium nitric oxide may play a role in insulin modulation of alpha2- and beta-adrenergic- evoked vascular responses. In particular, we examined the forearm blood flow response (FBF...
T V Hoang et al.
Journal of pediatric surgery, 31(12), 1659-1662 (1996-12-01)
To characterize neonatal mesenteric alpha-adrenoceptor populations, an extracorporeal perfusion circuit was established to control intestinal blood flow in prematurely delivered (by cesarean section at 90% of gestational age) piglets. Activation of alpha 1-adrenoceptors was documented by observing dose-dependent increases in...
H Kurvers et al.
Acta orthopaedica Belgica, 64(1), 64-70 (1998-05-20)
Sciatic nerve ligation in rats (chronic constriction injury (CCI)) induces clinical signs and symptoms that mimic human conditions of neuropathic origin, such as reflex sympathetic dystrophy (RSD). Denervation-induced supersensitivity to (circulating) catecholamines has been implicated in sympathetic dysfunction in the...
Enrique F Castillo et al.
Fundamental & clinical pharmacology, 20(4), 339-349 (2006-07-27)
In rat aorta, the presence of functional alpha(2)-adrenoceptors (alpha(2)-AR) was investigated in ring preparations preconstricted with alpha(1)-adrenergic and non- alpha(1)-adrenergic agonists. Particularly, the hypothetical interference of alpha(2)-AR agonists with alpha(1)-AR-mediated vasoconstriction was evaluated. Relaxant and contractile responses to alpha(2)-AR agonists...
Luis E Cobos-Puc et al.
European journal of pharmacology, 616(1-3), 175-182 (2009-06-17)
This study analysed the inhibition produced by the agonists moxonidine (imidazoline I(1) receptors>alpha(2)-adrenoceptors) and agmatine (endogenous ligand of imidazoline I(1)/I(2) receptors), using B-HT 933 (6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride; alpha(2)-adrenoceptors) for comparison, on the rat cardioaccelerator sympathetic outflow. Male Wistar rats were pithed...

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