B162

Sigma-Aldrich

B-HT 920 dihydrochloride

solid, ≥98% (HPLC)

Synonym(s):
Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride
Empirical Formula (Hill Notation):
C10H15N3S · 2HCl
CAS Number:
Molecular Weight:
282.23
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: >20 mg/mL

SMILES string

Cl.Cl.Nc1nc2CCN(CCc2s1)CC=C

InChI

1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H

InChI key

DPQAXNSOFFYKDS-UHFFFAOYSA-N

Gene Information

rat ... Drd2(24318)

Biochem/physiol Actions

α2-adrenoceptor agonist; D2 dopamine receptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
K Orito et al.
British journal of pharmacology, 134(4), 763-770 (2001-10-19)
1. Antagonistic properties of OPC-28326 ([4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl)] piperidine hydrochloride monohydrate), a selective peripheral vasodilator, were investigated by analysing the data from functional studies in various tissues from the rat and binding studies of the drug to alpha(2)-adrenoceptor subtypes. 2. Using a...
F Ferrari et al.
Life sciences, 70(13), 1501-1508 (2002-03-16)
Two experiments were performed to evaluate the effects of sildenafil on spontaneous or dopamine agonist-induced behaviour in male rats. Data obtained in experiment 1 show that oral administration of the drug, at 1 mg/kg, significantly increased the occurrence of penile...
A Gobert et al.
The Journal of pharmacology and experimental therapeutics, 305(1), 338-346 (2003-03-22)
In a dialysis procedure not requiring perfusate addition of acetylcholinesterase inhibitors to "boost" basal levels of acetylcholine (ACh), the influence of the antiparkinson agent piribedil upon levels of ACh in frontal cortex and dorsal hippocampus of freely moving rats was...
Keiko Shimizu et al.
Neuroscience research, 46(4), 523-532 (2003-07-23)
Paraquat (1,1'-dimethyl-4,4'-bipyridinium, PQ) is a herbicide to possibly induce Parkinson's disease (PD), since a strong correlation has been found between the incidence of the disease and the amount of PQ used. In this study, we examined PQ toxicity in rat...
Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.
C Pifl et al.
European journal of pharmacology, 146(1), 189-191 (1988-01-27)

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