P A Bland-Ward et al.
Life sciences, 57(11), PL131-PL135 (1995-01-01)
The effect of 7-nitro indazole (7-NI) and a range of substituted indazole derivatives on nitric oxide synthase (NOS) enzyme activity in homogenates of rat cerebellum, bovine endothelial cells and lung from endotoxin-pretreated rats was investigated. 3-bromo 7-nitro indazole was either...
M J O'Neill et al.
Brain research, 760(1-2), 170-178 (1997-06-20)
Recent studies have shown that the novel antioxidant LY231617 protects against ischaemia-induced neuronal damage in rat models of global cerebral ischaemia. In the present studies we have examined the effects of LY231617 in the gerbil model of global cerebral ischaemia....
K Wada et al.
Journal of neurosurgery, 89(5), 807-818 (1998-11-17)
Although nitric oxide (NO) has been shown to play an important role in the pathophysiological process of cerebral ischemia, its contribution to the pathogenesis of traumatic brain injury (TBI) remains to be clarified. The authors investigated alterations in constitutive nitric...
Carmen R Sunico et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(47), E7564-E7571 (2016-11-09)
Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox homeostasis. For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase widely expressed in mammalian neurons, inhibits both enzymatic activity and protective function against oxidative stress. Here, using...
Saurav Bhowmick et al.
Free radical biology & medicine, 113, 203-211 (2017-10-01)
Cerebral ischemia-reperfusion (I/R) injury initiates a cascade of events, generating nitric oxide (NO) and superoxide(O