from Curcuma longa (Turmeric), powder

Diferulylmethane, (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Natural Yellow 3
Linear Formula:
CAS Number:
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Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

biological source

Curcuma longa (Turmeric)

vapor density

13 (vs air)


≥65% (HPLC)




175  °C


ethanol: 10 mg/mL
DMSO: >11 mg/mL (lit.)(lit.)
0.5 M NaOH: soluble (then immediately dilute in PBS [lit.])(lit.)

storage temp.


SMILES string




InChI key


Gene Information

human ... APP(351), CYP1A2(1544)

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Curcumin has been used:
  • to measure its antibacterial activity in vitro
  • to determine its preventative effects for Alzheimer′s disease (AD) in mice
  • as a bifunctional agent for generation and validation of the erythroid 2-related factor 2 (Nrf2) reporter system
  • to study its in vitro inhibitory effects on human liver glucuronidation activity
  • to evaluate the effects of curcumin on Parkinson′s disease (PD)-like phenotypes


5, 10, 50 g in glass bottle

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Curcumin (diferuloylmethane) is a constituent of the yellow powder extracted from the roots of Curcuma longa Linn, also known as tumeric or turmeric. It is used as a spice and coloring agent for centuries. In addition, it is used to treat various diseases including, hepatic disorders, anorexia, diabetic wounds and rheumatism.


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Curcumin effectively rescued Parkinson?s disease-like phenotypes in a novel drosophila melanogaster model with dUCH Knockdown
Nguyen TT, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes
Ali RE and Rattan SIS
Annals of the New York Academy of Sciences, 1067(1), 394-399 (2006)
Dietary curcumin supplement influence on growth, immunity, antioxidant status, and resistance to Aeromonas hydrophila in Oreochromis niloticus
Mahmoud HK, et al.
Aquaculture (Amsterdam, Netherlands), 475, 16-23 (2017)
Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and alpha-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?
Sharman MJ, et al.
Neurobiology of Disease, 124, 505-519 (2019)
In vitro inhibitory effects of Andrographis paniculata, Gynura procumbens, Ficus deltoidea, and Curcuma xanthorrhiza extracts and constituents on human liver glucuronidation activity
Husni Z, et al.
Pharmacognosy magazine, 13(Suppl 2), S236-S236 (2017)
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
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