synthetic peptide corresponding to amino acids 7-21 of human CAMKK2.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CAMKK2 (7-21) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme encoded by the CAMKK2 gene in humans. CaMKK gene is located on human chromosome 12. It is also referred as CAMKK and CAMKKB. CAMKKB pathway is involved in the activation of AMP-activated protein kinase (AMPK) by baicalin and acts as an upstream kinase of AMPK in response to baicalin. Calmodulin (CaM) is used in many cellular Ca2+-dependent signaling cascades as intracellular Ca2+ receptor. It binds and activates enzyme CaM kinases (CaMKs). CaMKK2 is one of the most versatile among the calmodulin kinases. It phosphorylates and activates CaMKI, CaMKIV, and AMP-activated protein kinase. CAMKK plays an important role during human cytomegalovirus (HCMV)-mediated glycolytic activation and HCMV replication.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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