MilliporeSigma
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C6873

Sigma-Aldrich

Anti-CRABP2 (1-15) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):
Anti-CRABP-II, Anti-Cellular retinoic acid-binding protein 2, Anti-RBP6

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~16 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CRABP2(1382)

Immunogen

synthetic peptide corresponding to amino acids 1-15 of human CRABP2

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. : Anti-CRABP2 (1-15) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Biochem/physiol Actions

Cellular retinoic acid-binding protein 2 (CRABP-II )is a protein encoded by the CRABP2 gene in humans. These are low molecular weight proteins and their precise function is yet unknown. CRABP-II shuffles retinoic acid from cytoplasm into nucleus and form a complex with nuclear retinoic acid receptor to facilitate transcriptional activities of retinoic acid. Overexpression of CRABP-II is a late event of pancreatic carcinogenesis and can be used as a diagnostic marker. The gene is up-regulated in the endometrium of patients with unexplained recurrent spontaneous abortion. Altered expression of endometrial CRABP2 is involved in abnormal endometrium-trophoblast interaction, which leads to implantation failure. CRABP-II expression or methylation status may enable a personalized retinoic acid (RA) therapy in patients with medulloblastomas and other types of cancers.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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