synthetic peptide corresponding to amino acids 1-15 of human CRABP2
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. : Anti-CRABP2 (1-15) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Cellular retinoic acid-binding protein 2 (CRABP-II )is a protein encoded by the CRABP2 gene in humans. These are low molecular weight proteins and their precise function is yet unknown. CRABP-II shuffles retinoic acid from cytoplasm into nucleus and form a complex with nuclear retinoic acid receptor to facilitate transcriptional activities of retinoic acid. Overexpression of CRABP-II is a late event of pancreatic carcinogenesis and can be used as a diagnostic marker. The gene is up-regulated in the endometrium of patients with unexplained recurrent spontaneous abortion. Altered expression of endometrial CRABP2 is involved in abnormal endometrium-trophoblast interaction, which leads to implantation failure. CRABP-II expression or methylation status may enable a personalized retinoic acid (RA) therapy in patients with medulloblastomas and other types of cancers.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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