All Photos(2)

C7727

Sigma-Aldrich

Curcumin

≥94% (curcuminoid content), ≥80% (Curcumin)

Synonym(s):
Diferulylmethane, (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Natural Yellow 3
Linear Formula:
[HOC6H3(OCH3)CH=CHCO]2CH2
CAS Number:
Molecular Weight:
368.38
Colour Index Number:
75300
Beilstein:
2306965
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

vapor density

13 (vs air)

assay

≥80% (Curcumin)
≥94% (curcuminoid content)

form

powder

mp

175 °C

solubility

ethanol: 1 mg/mL
DMSO: >11 mg/mL
0.5 M NaOH: soluble (then immediately diluted in PBS)

storage temp.

−20°C

SMILES string

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key

VFLDPWHFBUODDF-FCXRPNKRSA-N

Gene Information

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General description

Curcumin is a yellow colored polyphenol obtained from the rhizome of Curcuma longa L. It is also known as diferuloyl methane, a symmetric molecule with a seven carbon linker connecting two o-methoxy phenolic groups containing aromatic rings. Curcumin is synthesized by Pabon′s reaction using vanillin and acetyl acetone in the presence of boric oxide. It constitutes an important part of various diets and herbal medicines, especially in the Asian continent for its various salubrious effects on human health.

Application

Curcumin has been used:
  • to study its in vitro effect on the inflammation and expression of tumour factor in patients with chronic kidney diseases
  • to determine its influence when used in combination with high frequency ultrasound on human cervical carcinoma cells
  • to study the possibility of using magnetic purification of curcumin from Curcuma longa by surface active maghemite nanoparticles (SAMNs)
  • to examine its effect on the amyloid-β peptide levels along with the maturation of amyloid-β precursor proteins in various cell lines and primary cortical neurons in mouse
  • as a supplement to evaluate its anti-carcinogenic and anti-apoptotic effect on cancer cells and cardiomyocytes
  • to test its anti-inflammatory effect in human promyelocytic leukemia cell line, the HL-60

Packaging

500 mg in poly bottle

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Curcumin is postulated to have anti-depressant, anti-stress and neuroprotective effects on humans and other animals. Additionally, it also shows anti-fungal, antiviral, anti-microbial, chemosensitizing, radiosensitizing, and wound healing activities.

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Cecilia M Shing et al.
Nutrition (Burbank, Los Angeles County, Calif.), 27(9), 967-972 (2011-02-08)
Nutritional compounds that potentially limit inflammation and tissue factor expression may decrease the progression of chronic kidney disease (CKD) and associated cardiovascular disease. This project aimed to determine the effect of curcumin, bovine colostrum, and fish oil on inflammatory cytokine...
The effect of turmeric extracts on inflammatory mediator production
Lantz RC, et al.
Phytomedicine, 12(6-7), 445-452 (2005)
The chemistry of curcumin: from extraction to therapeutic agent
Priyadarsini K
Molecules (Basel), 19(12), 20091-20112 (2014)
Gizem Calibasi-Kocal et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 24(4), 1482-1487 (2019-10-28)
Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, wound healing, anti-invasive and anti-migrative effects of curcumin...
Revisiting curcumin chemistry part I: A new strategy for the synthesis of curcuminoids
Rao EV and Sudheer P
Indian Journal of Pharmaceutical Sciences, 73(3), 262-262 (2011)

Articles

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