C9275

Sigma-Aldrich

Calcium Ionophore A23187 hemicalcium salt

powder

Synonym(s):
Antibiotic A 23187 hemicalcium salt, A23187 hemicalcium salt, Calimycin hemicalcium salt, Calcimycin hemicalcium salt
Empirical Formula (Hill Notation):
C29H36Ca0.5N3O6
CAS Number:
Molecular Weight:
542.65
Beilstein/REAXYS Number:
6765084
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

sterility

non-sterile

form

powder

color

yellow

solubility

DMSO: soluble
ethanol: soluble

Mode of action

cell membrane | interferes

antibiotic activity spectrum

Gram-positive bacteria
fungi

storage temp.

2-8°C

SMILES string

CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(=O)O[Ca]OC(=O)c6c(NC)ccc7oc(C[C@H]8O[C@@]9(CC[C@H]8C)O[C@@H]([C@H](C)C[C@H]9C)[C@H](C)C(=O)c%10ccc[nH]%10)nc67

InChI

1S/2C29H37N3O6.Ca/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t15-,16-,17-,18-,22-,27+,29?;15-,16-,17-,18-,22-,27+,29+;/m11./s1

InChI key

LAQWEYASNNRUGY-PLYBNSMSSA-L

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Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Packaging

1, 5 mg in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Lin Cai et al.
International journal of clinical oncology, 25(6), 1055-1066 (2020-02-28)
Filamin A is the most widely expressed isoform of filamin in mammalian tissues. It can be hydrolyzed by Calpain, producing a 90-kDa carboxyl-terminal fragment (ABP90). Calpeptin is a chemical inhibitor of Calpain, which can inhibit this effect. It has been...
Hong Liu et al.
American journal of physiology. Heart and circulatory physiology, 319(6), H1482-H1495 (2020-10-17)
Multiple organ perfusion is impaired in sepsis. Clinical studies suggest that persistent perfusion disturbances are prognostic of fatal outcome in sepsis. Pyroptosis occurs upon activation of caspases and their subsequent cleavage of gasdermin D (Gsdmd), resulting in Gsdmd-N (activated NH2-terminal...
Quan-Fang Zhang et al.
Frontiers in plant science, 11, 145-145 (2020-03-13)
Ceramide sphingolipids are major components of membranes. C2 and C6 ceramides induce programmed cell death (PCD) in animals and plants, and we previously showed that C2 and C6 ceramides induce PCD in rice (Oryza sativa) protoplasts. However, the mechanistic link...

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