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Anti-CtBP1, N-terminal antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Anti-Carboxy-terminal binding protein 1
MDL number:

biological source




antibody form

IgG fraction of antiserum

antibody product type

primary antibodies




buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

human, mouse


immunoprecipitation (IP): 5-10 μL using lysates of K562 cell line
microarray: suitable
western blot: 1:250-1:500 using mouse brain lysates
western blot: 1:500-1:1,000 using K562 cells

UniProt accession no.

shipped in

dry ice

storage temp.


Gene Information

human ... CTBP1(1487)
mouse ... Ctbp1(13016)


synthetic peptide corresponding amino acids 2-18 of human CtBP1. This sequence is conserved in mouse and does not cross-react with CtBP2.


Anti-CtBP1, N-terminal antibody produced in rabbit is suitable for immunoprecipitation and immunoblotting at a working dilution of 1:500-1:1000 using cell lysates of the K562 cell line and 1:250-1:500 using mouse brain lysates.

Biochem/physiol Actions

Apart from E1A protein, CtBP1 interacts with a wide variety of cellular factors such as DNA-binding transcription factors that participate in several developmental biological pathways and processes by binding to the carboxy terminal. It also interacts with polycomb group proteins and thus a component of the chromatin remodeling machinery and transcriptional repression. Pnn/DRS, a phosphoprotein involved in the regulation of cell adhesion and modulation of the activity of multiple tumor supressor genes, interacts with CtBP1 and may modulate repression of E-cadherin transcription. CtBP1 associates with SMAD6 and represses BMP signaling of the TGF-β pathway in the nucleus. It acts as transcriptional coregulator in histone acetyltransferase or histone deacetylase (HDAC)-dependent and independent manner.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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