MilliporeSigma
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C9872

Sigma-Aldrich

Anti-CIRBP (121-135) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):
Anti-CIRP, Anti-Cold-inducible RNA-binding protein
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~19 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CIRBP(1153)

General description

CIRBP is expressed in normal testes and downregulated after heat stress caused by cryptorchidism, varicocele or environmental temperatures.

Immunogen

synthetic peptide corresponding to amino acids 121-135 of human CIRBP

Application

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CIRBP antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000.

Biochem/physiol Actions

Extracellular CIRBP is a detrimental factor in stimulating inflammation to cause neuronal damage in cerebral ischemia. It may have a protective effect on testicular injury after testicular torsion/detorsion when upregulated. Downregulation of CIRBP has been shown to increase germ cell apoptosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificate of Analysis

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Certificate of Origin

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