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CS0080

Sigma-Aldrich

Epidermal Growth Factor Receptor ELISA human

sufficient for 96 tests

Synonym(s):
Epidermal Growth Factor Receptor ELISA, EGFR ELISA
Pricing and availability is not currently available.

usage

sufficient for 96 tests

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... EGFR(1956)

Application

Epidermal Growth Factor Receptor ELISA detects total EGFR in cell lysates.

Biochem/physiol Actions

EGFR, a member of the family of receptor tyrosine kinases, is a full length, type I transmembrane glycoprotein. In vivo phosphorylation of EGFR specific tyrosine sites, including Tyr1173 or Tyr1068, activates EGFR and downstream molecules.

Features and Benefits

EGFR ELISAs are fast (total time 4 hours), sensitive, and specific assays. The kit contains precoated plates, all incubations proceed at room temperature, and no proprietary equipment is required.

Analysis Note

Specifically measures both phosphorylated and non-phosphorylated forms of EGFR with a sensitivity of <0.08 ng/mL, which is 10 times more sensitive than immunoblotting.

RIDADR

UN 3316 9/PG 3

Certificate of Analysis
Certificate of Origin
Fredrik Jerhammar et al.
Oral oncology, 50(9), 832-839 (2014-07-06)
Targeted therapy against the epidermal growth factor receptor (EGFR) only variably represents a therapeutic advance in head and neck squamous cell carcinoma (HNSCC). This study addresses the need of biomarkers of treatment response to the EGFR-targeting antibody cetuximab (Erbitux®). The...
Mei-Chi Chang et al.
PloS one, 9(7), e101959-e101959 (2014-07-23)
Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa. Primary gingival keratinocytes (GK cells) were exposed to areca nut (AN) components...

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