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CS0150

Sigma-Aldrich

phospho-Epidermal Growth Factor Receptor (pTyr1068) ELISA human

sufficient for 96 tests

Synonym(s):
Epidermal Growth Factor Receptor ELISA, EGFR ELISA
Pricing and availability is not currently available.

usage

sufficient for 96 tests

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... EGFR(1956)

Application

phospho-Epidermal Growth Factor Receptor (pTyr1068) ELISA detects EGFR phosphorylated at tyrosine 1068 in cell lysates and biological fluids.

Biochem/physiol Actions

EGFR, a member of the family of receptor tyrosine kinases, is a full length, type I transmembrane glycoprotein. In vivo phosphorylation of EGFR specific tyrosine sites, including Tyr1173 or Tyr1068, activates EGFR and downstream molecules.

Features and Benefits

EGFR ELISAs are fast (total time 4 hours), sensitive, and specific assays. The kit contains precoated plates, all incubations proceed at room temperature, and no proprietary equipment is required.

Analysis Note

Specifically measures human EGFR protein phosphorylated on tyrosine 1068 with a sensitivity of <0.3 units/mL, which is 8 times more sensitive than immunoblotting. Does not detect non-phosphorylated EGFR.

RIDADR

UN 3316 9/PG 2

Certificate of Analysis
Certificate of Origin
A Bishayee et al.
Molecular biology of the cell, 10(3), 525-536 (1999-03-09)
We reported previously that a conformation-specific antibody, Ab P2, to a 16-amino acid peptide (Glu-Gly-Tyr-Lys-Lys-Lys-Tyr-Gln-Gln-Val-Asp-Glu-Glu-Phe-Leu-Arg) of the cytoplasmic domain of the beta-type platelet-derived growth factor receptor also recognizes the epidermal growth factor (EGF) receptor. Although the antibody is not directed...

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