Sandrine Ollagnier-de-Choudens et al.
FEBS letters, 532(3), 465-468 (2002-12-17)
Biotin synthase (BioB), an iron-sulfur enzyme, catalyzes the last step of the biotin biosynthesis pathway. The reaction consists in the introduction of a sulfur atom into two non-activated C-H bonds of dethiobiotin. Substrate radical activation is initiated by the reductive...
Travels with carbon-centered radicals. 5?-Deoxyadenosine and 5?-deoxyadenosine-5?-yl in radical enzymology
Accounts of Chemical Research, 47(2), 540-549 (2013)
Nicholas D Lanz et al.
Methods in enzymology, 516, 125-152 (2012-10-05)
An explosion of remarkable chemical transformations has been witnessed in the past decade as a result of the radical S-adenosyl-l-methionine (SAM) (RS) superfamily of proteins. These proteins share the ability to cleave SAM reductively to l-methionine and a 5'-deoxyadenosyl 5'-radical...
Alhosna Benjdia et al.
Journal of the American Chemical Society, 131(24), 8348-8349 (2009-06-06)
Sulfatases are unique in requiring an essential post-translational modification of a critical active-site cysteinyl or seryl residue to 3-oxoalanine usually called C alpha-formylglycine (FGly). This post-translational modification is catalyzed anaerobically by anaerobic Sulfatase Maturating Enzyme (anSME), a member of the...
Transition State Structure and Inhibition of Rv0091, a 5?-Deoxyadenosine/5?-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis
Namanja-Magliano, HA, et al.
ACS chemical biology, 11(6), 1669-1676 (2016)