D184

Sigma-Aldrich

Diethylamine NONOate sodium salt hydrate

≥97% (NMR)

Synonym(s):
Diethylamine/nitric oxide complex sodium salt hydrate, 2-(N,N-Diethylamino)-diazenolate 2-oxide sodium salt hydrate, DEA NONOate sodium salt hydrate, 1,1-Diethyl-2-hydroxy-2-nitroso-hydrazine sodium
Linear Formula:
(CH3CH2)2N–N(N=O)O- Na+ xH2O
Molecular Weight:
155.13 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

≥97% (NMR)

form

crystalline

storage condition

desiccated
protect from light

color

white

mp

45 °C (lit.)

solubility

H2O: >10 mg/mL
methanol: >25 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

O.Na+.CCN(CC)N(O-)N=O

InChI

1S/C4H10N3O2.Na.H2O/c1-3-6(4-2)7(9)5-8;;/h3-4H2,1-2H3;;1H2/q-1;+1;

InChI key

BVCZSYKIXSAMOT-UHFFFAOYSA-N

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Application

Diethylamine NONOate sodium salt hydrate has been used as a nitric oxide donor to evaluate endothelium-independent dilation. It has also been used to determine the level of nitric oxide in cell free systems.

Packaging

25, 50 mg in serum bottle

Biochem/physiol Actions

Diethylamine NONOate is a complex of diethylamine with nitric oxide used to generate a controlled release of nitric oxide in solution.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Nina Jeppesen Edin et al.
Journal of radiation research, 54(6), 1015-1028 (2013-05-21)
In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025)...
Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson?s Disease Etiopathology
Wilkaniec A, et al.
Molecular Neurobiology, 56(1), 125-140 (2019)
High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function
Toklu HZ, et al.
Journal of Physiology And Pharmacology, 67(2), 205-205 (2016)
The functional and structural changes in the basilar artery due to overpressure blast injury
Toklu HZ, et al.
Journal of Cerebral Blood Flow and Metabolism, 35(12), 1950-1956 (2015)
Alice Miriam Kitay et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(4), 1606-1615 (2017-12-07)
L-arginine is an important mediator of cell division, wound healing, and immune function. It can be transformed by the nitric oxide synthase (NOS) to nitric oxide (NO), an important cell signaling molecule. Recent studies from our laboratory demonstrate specific effects...
Articles
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
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