Diphenhydramine hydrochloride

≥98% (HPLC)

N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride, 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride
Empirical Formula (Hill Notation):
C17H21NO · HCl
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


≥98% (HPLC)




Johnson & Johnson

SMILES string




InChI key


Gene Information

human ... HRH1(3269)

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Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies


5, 50, 100 g in glass bottle

Biochem/physiol Actions

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


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Signal Word


Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

R U Agu et al.
Pharmaceutical research, 16(9), 1380-1385 (1999-09-25)
To test two in vitro human nasal epithelial cell culture systems for their ability to screen the effects of pharmaceutical compounds on ciliary beating. Human nasal epithelial cells were cultured as monolayer and in a sequential monolayer-suspension culture with in...
Pharmacologic characterization of AMG8379, a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV1. 7
Kornecook TJ, et al.
Journal of Pharmacology and Experimental Therapeutics, 362(1), 146-160 (2017)
Simultaneous determination of pseudoephedrine hydrochloride and diphenhydramine hydrochloride in cough syrup by gas chromatography (GC)
Raj SV, et al.
Talanta, 46(1), 221-225 (1998)
Reevaluation of the embryonic stem cell test
Inselman AL, et al.
International journal of regulatory science, 1(1), 32-49 (2013)
Clinical evaluation of diphenhydramine hydrochloride for the treatment of insomnia in psychiatric patients: a double-blind study
Kudo Y and Kurihara M
Journal of Clinical Pharmacology, 30(11), 1041-1048 (1990)

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