(±)-trans-U-50488 methanesulfonate salt

trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate salt, U-50488H
Empirical Formula (Hill Notation):
C19H26Cl2N2O · CH4O3S
Molecular Weight:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level


H2O: 50 mg/mL

storage temp.


SMILES string




InChI key


Gene Information

human ... OPRK1(4986)


(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.


10 mg in poly bottle
50, 100 mg in glass bottle

Biochem/physiol Actions

Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
Chajra H, et al.
International Journal of Cosmetic Science, 37(4), 386-394 (2015)
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
Beardsley PM, et al.
Psychopharmacology, 183(1), 118-118 (2005)
Pharmacology and Therapeutics in the New Millennium, 462-462 (2001)
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain
Basile AS, et al.
Journal of Pharmacology and Experimental Therapeutics, 321(3), 1208-1225 (2007)
X C Yu et al.
Journal of molecular and cellular cardiology, 31(10), 1809-1819 (1999-10-20)
During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations. Since beta-adrenoceptor is negatively modulated by the kappa-opioid receptor in the heart, the present study attempted to determine if kappa-opioid receptor...

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