E3149

Sigma-Aldrich

S-Ethylisothiourea hydrobromide

≥98%

Synonym(s):
2-Ethyl-2-thiopseudourea hydrobromide
Empirical Formula (Hill Notation):
C3H8N2S · HBr
CAS Number:
Molecular Weight:
185.09
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

assay

≥98%

storage temp.

2-8°C

SMILES string

BrH.CCSC(N)=N

Biochem/physiol Actions

Inhibitor of inducible human, endothelial and neuronal nitric oxide synthetase isozymes.
G J Southan et al.
British journal of pharmacology, 114(2), 510-516 (1995-01-01)
1. The induction of a calcium-independent isoform of nitric oxide (NO) synthase (iNOS) and a subsequent enhanced formation of NO has been implicated in the pathophysiology of a variety of diseases including inflammation and circulatory shock. Here we demonstrate that...
E P Garvey et al.
The Journal of biological chemistry, 269(43), 26669-26676 (1994-10-28)
S-Ethylisothiourea was a potent competitive inhibitor of human nitric oxide synthase (NOS), with Ki values of 17, 36, and 29 nM for the inducible (i), endothelial (e), and neuronal (n) isozymes, respectively. Unlike some potent inhibitors of NOS, no time...

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