E7280

Sigma-Aldrich

Elafin human

>90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

MDL number:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

recombinant

expressed in Saccharomyces cerevisiae

assay

>90% (by MS, HPLC and SDS-PAGE)

form

powder

potency

1.7 x 10-10 M Ki (human leukocyte elastase)
4.2 x 10-10 M Ki (human proteinase 3)

mol wt

~6 kDa

Mode of action

enzyme | inhibits

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PI3(5266)

General description

Chemical structure: peptide

Biochem/physiol Actions

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
T Dau et al.
Scientific reports, 6, 35413-35413 (2016-10-16)
High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied...
Viraj J Jasinghe et al.
BioResearch open access, 2(2), 128-137 (2013-04-18)
Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both...
Renata Curciarello et al.
Journal of inflammation research, 13, 233-243 (2020-06-18)
Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive...
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum...
J A Caruso et al.
Oncogene, 34(27), 3556-3567 (2014-09-10)
The serine protease inhibitor, elafin, is a critical component of the epithelial barrier against neutrophil elastase (NE). Elafin is downregulated in the majority of breast cancer cell lines compared with normal human mammary epithelial cells (HMECs). Here, we evaluated the...
Articles
Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.
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