E7907

Sigma-Aldrich

Anti-EFNA1 (151-165) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):
Anti-B61, Anti-EPLG1, Anti-Ephrin A1 isoform a precursor, Anti-TNFAIP4, Anti-ECKLG, Anti-LERK1, Anti-EFL1

biological source

rabbit

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~24 kDa

species reactivity

human

application(s)

western blot: 1:500-1:2,000

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... EFNA1(1942)

Immunogen

synthetic peptide corresponding to amino acids 151-165 of human EFNA1.

Application

Anti-EFNA1 (151-165) antibody produced in rabbit is suitable for western blotting (1:500-1:2,000) and immunofluorescence.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Ephrin-A1 is a protein encoded by the EFNA1 gene in humans. It is involved with numerous physiological processes and plays a role in various malignancies. EFNA1 expression is highly induced by hypoxia and acts as a useful marker for predicting high risk of relapse and cancer-related death. It is an independent prognostic factor for colorectal cancer (CRC). EFNA1 can promote cell attachment and intercellular dissociation in Ishikawa cells. It plays an important role in the initial step of embryo implantation by opening the endometrial epithelial cell barrier.

Features and Benefits

Ephrin-A1 is a protein encoded by the EFNA1 gene in humans. It is involved with numerous physiological processes and have role in various malignancy. EFNA1 expression is highly induced by hypoxia and acts as a useful marker for predicting high risk of relapse and cancer-related death. It is an independent prognostic factor for colorectal cancer (CRC). EFNA1 can promote cell attachment and intercellular dissociation in Ishikawa cells. It plays an important role in the initial step of embryo implantation by opening the endometrial epithelial cell barrier.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Certificate of Analysis

Certificate of Origin

Hirofumi Yamamoto et al.
International journal of oncology, 42(2), 549-555 (2012-12-22)
We previously studied hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC) and determined several potential prognostic factors, including expression ...
Haruko Fujii et al.
Human reproduction (Oxford, England), 26(5), 1163-1170 (2011-02-26)
Recently, the Eph-ephrinA system was proposed to contribute to the initial interaction between the maternal endometrial epithelium and embryonic trophectoderm. Since the Eph-ephrin interaction can induce adhesive and/or repulsive forces into the cells, we examined the possible role of this...
Haruko Fujii et al.
Human reproduction (Oxford, England), 26(2), 299-306 (2010-12-09)
During implantation, the human embryo invades endometrial stromal tissues, reducing the intercellular connections among epithelial cell layers. Since Eph-ephrin interaction can induce repulsive forces to control cell position and movement, we examined the possible involvement of this system in intercellular...
Amanda Beauchamp et al.
Seminars in cell & developmental biology, 23(1), 109-115 (2011-11-02)
Ephrin-A1 and its primary receptor, EphA2, are involved in numerous physiological processes and have been intensely studied for their roles in malignancy. Ephrin-Eph signalling is complex on its own and is also cell-type dependent, making elucidation of the exact role...
Chary Marquez Batista et al.
Neural plasticity, 2014, 451639-451639 (2014-08-12)
Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown. Rats received a low thoracic SC photothrombotic ischemia and local injection of...

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