Rajib K Paul et al.
The Journal of pharmacology and experimental therapeutics, 343(1), 157-166 (2012-07-11)
Inhibition of cell proliferation by fenoterol and fenoterol derivatives in 1321N1 astrocytoma cells is consistent with β(2)-adrenergic receptor (β(2)-AR) stimulation. However, the events that result in fenoterol-mediated control of cell proliferation in other cell types are not clear. Here, we...
Dorota Latek et al.
Journal of molecular modeling, 17(9), 2353-2366 (2011-03-03)
Cannabinoid and adrenergic receptors belong to the class A (similar to rhodopsin) G protein coupled receptors. Docking of agonists and antagonists to CB(1) and CB(2) cannabinoid receptors revealed the importance of a centrally located rotamer toggle switch and its possible...
Bart G J Dekkers et al.
The Journal of pharmacology and experimental therapeutics, 342(3), 780-787 (2012-06-12)
Airway remodeling, including increased airway smooth muscle (ASM) mass and contractility, contributes to increased airway narrowing in asthma. Increased ASM mass may be caused by exposure to mitogens, including platelet-derived growth factor (PDGF) and collagen type I, which induce a...
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