All Photos(1)

F112

Sigma-Aldrich

(+)-Fenfluramine hydrochloride

Synonym(s):
Dexfenfluramine hydrochloride, (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride
Empirical Formula (Hill Notation):
C12H16F3N · HCl
CAS Number:
Molecular Weight:
267.72
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

powder

Quality Level

drug control

USDEA Schedule IV

color

white to off-white

solubility

H2O: soluble 10 mg/mL

Featured Industry

Forensics and Toxicology

storage temp.

room temp

SMILES string

Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1

InChI key

ZXKXJHAOUFHNAS-FVGYRXGTSA-N

Biochem/physiol Actions

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

Other Notes

Active isomer

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

L Rochette et al.
Annales de cardiologie et d'angeiologie, 57(3), 136-138 (2008-06-27)
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Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist/inverse-agonist therapies.
Sara Jane Ward et al.
Obesity (Silver Spring, Md.), 19(7), 1325-1334 (2011-04-09)
James P Collman et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(26), 10528-10533 (2009-06-23)
O(2) reactivity of a functional NOR model is investigated by using electrochemistry and spectroscopy. The electrochemical measurements using interdigitated electrodes show very high selectivity for 4e O(2) reduction with minimal production of partially reduced oxygen species (PROS) under both fast...
Ioannis Papazoglou et al.
Molecular and cellular endocrinology, 350(1), 136-144 (2012-01-03)
Serotonin and insulin are key regulators of homeostatic mechanisms in the hypothalamus. However, in type 2 diabetes, the hypothalamic responsiveness to serotonin is not clearly established. We used a diabetic model, the Goto Kakizaki (GK) rats, to explore insulin receptor...
Korneel Rabaey et al.
Current opinion in biotechnology, 22(3), 371-377 (2011-03-01)
The production of biofuels and biochemicals is highly electron intensive. To divert fermentative and respiratory pathways to the product of interest, additional electrons (i.e. reducing power) are often needed. Meanwhile, the past decade has seen the breakthrough of sustainable electricity...

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