FMR1 is a member of a small protein family that consists of FMR1, FXR1, and FXR2. FMR1, also known as FMRP, FRAXA and Fragile X mental retardation 1 protein, is localized to the cytoplasm with two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one RGG box. The protein is highly expressed in brain and testis.
synthetic peptide corresponding to amino acids 122-136 of human FMR1, conjugated to KLH. The corresponding sequence is highly conserved (1 amino acid substitution) in rat and mouse.
Anti-FMR1 (N-terminal) antibody is suitable for western blot at a concentration of 0.5-1.0μg/mL, using lysates of HEK-293T cells.
The FMR1 protein can binds RNA in vitro including two KH domains and an RGG box, which further influences the association with polyribosomes in vivo. It also contains a 60S ribosomal subunit interaction domain and a protein-protein interaction domain which triggers homomer and heteromer formation with each family member. Defects in FMR1 gene activity cause Fragile X syndrome, a common inherited form of mental retardation.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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