GR 55562 dihydrobromide

>97% (HPLC), powder

3-3-(Dimethylamino)propyl-4-hydroxy-N-4-(4-pyridinyl)phenylbenzamide dihydrobromide
Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
Molecular Weight:
MDL number:
Pricing and availability is not currently available.


Store tightly sealed with desiccant.


>97% (HPLC)




light yellow


H2O: ~12 mg/mL (with mixing)

storage temp.




InChI key


Biochem/physiol Actions

5-HT1B/5-HT1D serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Certificate of Analysis
Certificate of Origin
Iwona Papla et al.
Polish journal of pharmacology, 54(4), 351-357 (2003-01-14)
Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study...
Lucía Martínez-Mota et al.
Psychopharmacology, 165(1), 60-66 (2002-12-11)
Indorenate has been proposed to possess antihypertensive, anorectic, stimulus control and anxiolytic-like actions. This compound has affinity mainly for the serotonergic(1A/1B) receptors, hence it could possess antidepressant-like activity. The general purpose of this study was to explore the possible antidepressant-like...
Kayi Y Chan et al.
European journal of pharmacology, 619(1-3), 61-67 (2009-07-22)
Tegaserod, a 5-HT(4) receptor agonist, has been used to treat idiopathic constipation and constipation-predominant irritable bowel disease. It has recently been suggested that tegaserod has an affinity for 5-HT(1B) receptors, which mediate vasoconstriction. As some patients have experienced cardiac ischemia...
Satoshi Matsusaka et al.
FEBS letters, 579(30), 6721-6725 (2005-11-29)
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement was completely inhibited by GR 55562, a 5-HT1...
Małgorzata Filip et al.
Naunyn-Schmiedeberg's archives of pharmacology, 366(3), 226-234 (2002-08-13)
Recent data indicate a significant input of serotonin (5-HT) on mesoaccumbens dopamine-dependent behavioral effects of cocaine in rats. The present study investigated the role of 5-HT(1B) receptors in nucleus accumbens subregions (the shell and the core) and the effect of...

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