G0419

Sigma-Aldrich

GR 55562 dihydrobromide

>97% (HPLC), powder

Synonym(s):
3-3-(Dimethylamino)propyl-4-hydroxy-N-4-(4-pyridinyl)phenylbenzamide dihydrobromide
Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
Molecular Weight:
537.29
MDL number:
Pricing and availability is not currently available.

description

Store tightly sealed with desiccant.

assay

>97% (HPLC)

form

powder

color

light yellow

solubility

H2O: ~12 mg/mL (with mixing)

storage temp.

2-8°C

InChI

1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H

InChI key

NUDSRNNZTVHCKY-UHFFFAOYSA-N

Biochem/physiol Actions

5-HT1B/5-HT1D serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
Iwona Papla et al.
Polish journal of pharmacology, 54(4), 351-357 (2003-01-14)
Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study...
Lucía Martínez-Mota et al.
Psychopharmacology, 165(1), 60-66 (2002-12-11)
Indorenate has been proposed to possess antihypertensive, anorectic, stimulus control and anxiolytic-like actions. This compound has affinity mainly for the serotonergic(1A/1B) receptors, hence it could possess antidepressant-like activity. The general purpose of this study was to explore the possible antidepressant-like...
Kayi Y Chan et al.
European journal of pharmacology, 619(1-3), 61-67 (2009-07-22)
Tegaserod, a 5-HT(4) receptor agonist, has been used to treat idiopathic constipation and constipation-predominant irritable bowel disease. It has recently been suggested that tegaserod has an affinity for 5-HT(1B) receptors, which mediate vasoconstriction. As some patients have experienced cardiac ischemia...
Satoshi Matsusaka et al.
FEBS letters, 579(30), 6721-6725 (2005-11-29)
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement was completely inhibited by GR 55562, a 5-HT1...
Małgorzata Filip et al.
Naunyn-Schmiedeberg's archives of pharmacology, 366(3), 226-234 (2002-08-13)
Recent data indicate a significant input of serotonin (5-HT) on mesoaccumbens dopamine-dependent behavioral effects of cocaine in rats. The present study investigated the role of 5-HT(1B) receptors in nucleus accumbens subregions (the shell and the core) and the effect of...

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